|Spoiler warning: Plot or ending details follow.|
Prayer:Convergence is the twenty-second and the last episode of the Guilty Crown anime. It first aired on March 22, 2012
As Mana awakes, a stream of pink energy starts to spread at Earth, while Arugo wonders about the what happened, he decides to have himself and Ayase hold back Daryl Yan. While Tsugumi is having trouble taking control of the building, Shibungi thinks there is only one person is equal to Tsugumi, showing Kenji on a keyboard. Mana greets Gai and runs up to Shu as if she is still normal. She gloats that she has taken Inori's body for herself and called her a fake and a monster, and that they can be together this time. Shu became angry with this and throws her off himself, saying Inori was human, and Mana is the monster. She attempted to kill him for his second rejection, only to be stopped by Gai, who states he will kill Shu. Gai draws Mana's void which is the same as Inori's. While Mana starts the Fourth Apocalypse. And due to the large genomic resonance, the UN Endlave system is not functioning, which Daryl happily states is due to their old technology. While Arugo is able to attack the ghost units, he is unable to hit Daryl due to a device called the void genome emulator, that allows him to use his own void while piloting. Ayase tries to connect to her Endlave with a cable, but is stopped by Daryl.
Shu uses his void to defend, but as time progress Shu is overpowered by Gai. While Shu asked why his objectives have changed from Roppongi, Gai states Shu can never understand. As he was chosen as Adam but refused to do so. Gai also states the fourth Apocalpse will turn humans into crystals, but they will remain conscious. While Haruka Ouma meets Shuichiro Keido, and she points a gun at him asking, if he did this to the world just to beat Kurosu Ouma, which he refused to disagree.
As Shu is weakened, he notices the flower that Inori's tears made, and Inori's soul still existed in it. That allowed Shu to use his void to extract Inori's void, and lets Inori's soul to disrupt Mana. As Inori's fights Mana, Daryl is slowed down, and Kenji's computer is stopped, right before Shibungi kills him. Shu using Inori's void was able to equal and then overpower Gai, killing him. While Inori's interfence allows Ayase to connect to her Steiner and have Tsugumi remote control part of the Steiner and defeat Daryl. Shuichiro then takes an injection that causes him to get the Apocalypse Virus, and he states in the end neither he nor Kurosu won, and tells his sister to leave.
After killing Gai, Shu then somewhat began to hallucinate and he started to see visions of places from his past with Gai introducing him to the place. Gai then explained that the real purpose of Daath is the evolution of mankind through living only in their memories. Gai then takes Shu in the same church where Lost Christmas occured, with Mana and young Gai still there. Gai reveals the only way to stop Mana was to allow her to fulfill her purpose, and he wanted Shu to defeat them.
This time, Gai embraces Mana with blood flowing from them and both of them crystallizing. Before they completely crystallize, Gai tells Shu to save Inori. Back to reality, Shu sees Inori blindly walking towards him and almost crystallized. Shu embraces Inori and started to cry while activating his Void (combined with Gai as Gai died and so his void also binded with Shu), Shu's void starts to absorb all the Voids and the Apocalypse Virus (essentially removing all the voids in the process) which resulted to the breakdown of the GHQ Headquarters and other Void-powered devices losing power.
Shu then begins to crystallize with Inori and started hallucinating about the first time she took Inori's Void and was reluctant but this time, he accepted the a Cat's Cradle. As Inori started to fade away, Shu tries to reach for her but she suddenly disappeared and in reality, she crystallized completely and breaks down. But as GHQ building is collapsing Shu is left in the building, while his allies are forced to escape.
A few years later, all is back to normal in Japan and a video of Inori singing Departures is seen playing on an LCD panel of a building. Inside the building, a comemoration is going to take place between Ayase, Yahiro (who now has a job), Souta, Tsugumi (who is going to take a teacher's licensure exam), Kanon, and Shu. Shu is the last one to arrive at the dining place. Shu is seen walking with a cane stick as a result of his blindness and with his right arm replaced by a prosthetic one. Shu says he's glad to celebrate with everyone again as they started the celebration. Shu is then last seen at a bench facing the sea, as Shu sits and gets an earpiece, then the screen shows Shu hugging Inori and a montage of Shu and Inori together.